The recommended dosage of DIFLUCAN for esophageal candidiasis is 200 mg on the first day, followed by 100 mg once daily. Doses up to 400 mg/day may be used, based on medical judgment of the patient's response to therapy Esophageal Candidiasis. Esophageal candidiasis: 6 mg/kg PO on Day 1, THEN 3 mg/kg qDay . Doses up to 12 mg/kg/day may be used, based on patient's response. Dosing considerations. Treat for a minimum of 3 weeks and for at least 2 weeks following resolution of symptoms; Systemic Candida Infections. 6-12 mg/kg/day PO/IV; not to exceed 600 mg/da In order to evaluate the efficacy of 200 mg single weekly dose of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS, 18 patients who had an endoscopic confirmation of cure after an esophageal candidiasis, were studied
Esophageal candidiasis fluconazole treatment February 10, 2019 by admin Candidiasis of the esophagus is one of the manifestations of the general defeat of the gastrointestinal tract by pathogenic microorganisms PLD-118, formerly BAY 10-8888, is a synthetic antifungal derivative of the naturally occurring beta-amino acid cispentacin. We studied the activity of PLD-118 in escalating dosages against experimental oropharyngeal and esophageal candidiasis (OPEC) caused by fluconazole (FLC)-resistant Candida albicans in immunocompromised rabbits 3-6 mg/kg, dose to be given on first day, then 3 mg/kg daily (max. per dose 100 mg) for 7-14 days in oropharyngeal candidiasis (max. 14 days except in severely immunocompromised patients); for 14-30 days in other mucosal infections (e.g. oesophagitis, candiduria, non-invasive bronchopulmonary infections). For Child 12-17 year The recommended dose of fluconazole for the treatment of esophageal candidiasis in adults is 200 mg on the first day, followed by 100 mg to 400 mg once daily. The recommended dose of fluconazole for the treatment of systemic candida infections in adults is up to 400 mg once daily esophageal candidiasis. For the treatment of esophageal candidiasis, the recommended dosage of DIFLUCAN in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Doses up to 12 mg/kg/day may be used, based on medical judgment of the patient's response to therapy
. ›. Pharmacology of azoles. intravenous (IV) preparations, fluconazole is very hydrophilic and is almost completely absorbed following oral administration; the reported bioavailability is over 90 percent . Fluconazole absorption is not affected . ›. Esophageal candidiasis in adults Esophageal candidiasis. Esophageal candidiasis requires systemic treatment. Oral fluconazole at 200 mg/day for 14-21 days will resolve symptoms in over 80% of patients within a week. Initial therapy with intravenous preparations may be needed in patients who have severe odynophagia or dysphagia
PLD-118, formerly BAY 10-8888, is a synthetic antifungal derivative of the naturally occurring β-amino acid cispentacin. We studied the activity of PLD-118 in escalating dosages against experimental oropharyngeal and esophageal candidiasis (OPEC) caused by fluconazole (FLC)-resistant Candida albicans in immunocompromised rabbits. Infection was established by fluconazole-resistant (MIC > 64. V-echinocandin (VER-002; LY303366) is a semisynthetic derivative of echinocandin B and a potent inhibitor of fungal (1, 3)-β-d-glucan synthase. We studied the antifungal efficacy, the concentrations in saliva and tissue, and the safety of VER-002 at escalating dosages against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant Candida albicans in. dose of fluconazole (200 mgiday) in the last 5 weeks. Twenty-two of the 3 1 episodes (7 1%) of recurrent esophageal candidiasis were associated with esophageal symptoms, and only nine (29%) were associated with oral thrush. Recurrent symptoms occurred 25 times i with more drug-drug interactions than fluconazole. Esophageal Candidiasis Systemic antifungals are required for effective treatment of esophageal candidiasis (AI). A 14-day to 21-day course of either fluconazole (oral or intravenous [IV]) or oral itraconazole solution is highly effective (AI). However, patients with severe symptoms initially.
The normal dose of fluconazole is 200 mg on first day and 100mg daily for atleast 2weeks. Oral and esophageal candidiasis responds to 100-200mg daily. This dose is used in high risk individuals. It has adverse effects like nausea, vomiting, Diarrhoea. You can take antiemetics if you have vomiting problems Peds Dosing . Dosage forms: TAB: 50 mg, 100 mg, 150 mg, 200 mg; SUSP: 10 mg per mL, 40 mg per mL Dosage Forms Discontinued in US [IV not avail. as brand; see generic] candidiasis, systemic [29 wk gestation, 0-14 days old]Dose: 6 mg/kg/dose PO/IV q72h for >3wk; Start: 12 mg/kg/dose PO/IV x Esophageal candidiasis is an infection with multiple known rare complications and is commonly encountered in immunosuppressed patients (1). However, symptomatic esophageal candidiasis is rarely encountered in patients with intact host defence mechanisms, despite the fact that Candida can colonize the esophagus in up to 20% of healthy adults (2,3) Fluconazole 100 to 200 mg three times per week can be used to suppress recurrent esophageal candidiasis. Micafungin 150 mg IV daily has been shown to be non-inferior to fluconazole at 200 mg daily. Itraconazole 200 mg per day orally or Voriconazole 200 mg twice daily for 14 to 21 days are other treatment options
Fluconazole administration usually requires multiple doses except in vaginal candidiasis, where the recommended dosage is 150 mg as a single oral dose. The doses range from 200 mg on the first day, followed by 100 mg once daily as in oropharyngeal and esophageal candidiasis, to daily doses of 50 to 200 mg in the treatment of Candida peritonitis. Esophageal Candidiasis. Adult: 200 mg orally on Day 1, THEN 100 mg once/day; Convenience and efficacy of single dose oral tablet of fluconazole regimen for the treatment of vaginal yeast infections should be weighed against acceptability of higher incidence of drug related adverse events with fluconazole. Esophageal candidiasis (EC), occurring with or without oropharyngeal involvement, has a reported mean incidence of 10%-15% in patients with AIDS .Candida albicans is the predominant infecting fungal pathogen in HIV-positive patients, representing approximately 70%-80% of oral isolates, followed by Candida glabrata and Candida tropicalis, each of which accounts for 5%-8% of infections  A total of 6 (14.28%) samples were resistant to fluconazole, while 2 (4.76%) samples had dose depending susceptibility to this drug. CONCLUSIONS: Esophageal candidiasis prevalence was low, although within the results described by other authors
A little more than half (51.9%) of 77 patients with esophageal candidiasis also had esophageal symptoms. Our findings and those of other studies support the observation that esophageal candidiasis could be suspected if oral thrush is present, especially when esophageal symptoms are associated (10,14,26,27) Antifungal resistance is an increasing problem with the fungus Candida, a yeast. Candida infections may resist antifungal drugs, making them difficult to treat.. About 7% of all Candida blood samples tested at CDC are resistant to the antifungal drug fluconazole.Although one Candida species, Candida albicans, is the most common cause of severe Candida infections, resistance is most common in. Empiric treatment of esophageal candidiasis with fluconazole recommended in pts with recent onset of retrosternal pain or odynophagia, especially if accompanied by oral candidiasis. Limited drug interactions with ARVs, but fluconazole may increase amodiaquine (CYP2C8 substrate) and proguanil (CYP2C19) serum concentrations The standard recommended dose for fluconazole is 800 mg as the loading dose, followed by fluconazole at a dose of 400 mg/d for at least 2 weeks of therapy after a demonstrated negative blood.
Candidemia is often fatal, especially in patients with persistent neutropenia. New therapies are needed. We performed 24-h pharmacodynamic studies to compare the efficacies of anidulafungin, fluconazole, and amphotericin B in neutropenic mice with disseminated candidiasis caused by one of three strains of Candida glabrata. Anidulafungin produced a maximal fungal kill (Emax) of 1.4 to 1.9 log10. Esophageal candidiasis: This type of candidiasis occurs deep down in the throat and can't always be seen by looking into the mouth. It can cause chest pain, as well as pain and difficulty when swallowing. Fluconazole (Diflucan): One 150 mg dose of this tablet is taken for uncomplicated candidiasis. It should not be used during pregnancy what is the dose of nystatin tablets for a flucanazole resistant oral thrush, esophageal and intestinal candidiasis for an adult? and for how long should be taken? 1 doctor answer • 1 doctor weighed in. Need to speak with a doctor to get. Candida resistance to fluconazole is extremely rare and very unlikely. May be another condition entirely Esophageal candidiasis: For the treatment of esophageal candidiasis, the recommended dosage of fluconazole in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Doses up to 12 mg/kg/day may be used based on medical judgment of the patient's response to therapy Esophageal candidiasis: The recommended dosage of fluconazole for esophageal candidiasis is 200 mg on the first day, followed by 100 mg once daily. Doses up to 400 mg/day may be used, based on medical judgment of the patient's response to therapy. Patients with esophageal candidiasis should be treated for a minimum of three weeks and for at.
Esophageal candidiasis is a frequent cause of morbidity in immunocompromised patients. Isavuconazole is a novel, broad-spectrum antifungal developed for the treatment of opportunistic fungal infections. This phase 2 trial compared the efficacy and safety of three oral dosing regimens of isavuconazole with an oral fluconazole regimen in the primary treatment of uncomplicated esophageal. Oral candidiasis is a clinical sign found in 50-95% of HIV/AIDS patients 2. Based on the recommendation of World Health Organization (WHO), the early management of oral candidiasis in HIV/AIDS patients uses fluconazole at a dose of 100 mg/day for 7-14 days. Nystatin can be used as an alternative if the fluconazole dose does not show any. and esophageal candidiasis.6 While the findings of this review article suggest that micofungin is noninferior to fluconazole or caspofungin for the treatment of esophageal candidiasis, the clinical question was to evaluate whether anidulafungin specifically is an effective alternative to fluconazole To treat esophageal candidiasis, the recommended adult dose ranges from 100 mg to 200 mg for at least 21 days. The average assigned dose per day to treat vaginal yeast infections is 150 mg. Because it fights with fungus only through the bloodstream, this medicine can't be administered topically 2. Dosage and Administration in Children Drug: FLUCONAZOLE injection Pediatric Patients dosing: 3mg/kg 6mg/kg 12*mg/kg Fluconazole Injection indication for use insert: Esophageal candidiasis: For the treatment of esophageal candidiasis, the recommended dosage of fluconazole in children is 6mg/kg on the first day, followed by 3 mg/kg once daily
Esophageal candidiasis : For esophageal candidiasis, fluconazole is the drug of choice. It is given at dose of 3 mg/kg/day IV for 21 days changing to oral route once the child starts tolerating food. Itraconazole capsule is not useful for treatment of esophageal candidiasis, however oral solution may be given for 14-21 days . Similarly, micafungin at a dose of 150 mg/day (n = 59) was similar in efficacy to fluconazole 200 mg/day (n = 60) for esophageal candidiasis (89.8% vs 86.7% response rate, respectively) in a randomized, double-blinded, multicenter study Esophageal candidiasis is one of the most common opportunistic fungal infections in immunocompromised patients, including human immunodeficiency virus (HIV)-positive patients and those who are immunosuppressed as a result of underlying diseases or medications (2, 35).A number of agents have been used to treat esophageal candidiasis, including nystatin, miconazole, ketoconazole, fluconazole.
, such as vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of abdomen or stomach], an Fluconazole 200 MG Tablet is an anti-fungal agent. It is used to prevent and treat infections caused by fungi and yeasts. It acts by stopping the growth and multiplication of these organisms. Buy Fluconazole 200 MG Tablet Online. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Download Practo app.
MANAGEMENT 1,8-10. The preferred treatment of oropharyngeal candidiasis differs based on patient-specific factors. The average duration of therapy is 7 to 14 days. For esophageal candidiasis 14 to 21 day-duration of therapy is recommended. When choosing an agent, one must consider drug efficacy for the identified strain and site of infection. A dose-response study of 245 patients compared micafungin so- dium 50, 100, and 150 mg i.v. daily with fluconazole 200 mg p.o. daily for the treatment of endoscopically confirmed esophageal. In summary, the echinocandin VER-002 was well tolerated, penetrated the esophagus and salivary glands, and demonstrated dosage-dependent antifungal activity against fluconazole-resistant esophageal candidiasis in immunocompromised rabbits Fluconazole Mechanism : Fluconazole interacts with 14-a demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents . In the case of itraconazole, oral absorption is somewhat unpredictable.
It was approved by the FDA in 1992 for the treatment of certain fungal infections, including esophageal candidiasis, oral thrush, histoplasmosis (also referred as Histoplasma capsulatum infection), and oropharyngeal candidiasis. Dosage. For oral candidiasis, the recommended dose is 100 mg per day for 14 days. Side Effects And Precaution Description and Brand Names. Drug information provided by: IBM Micromedex US Brand Name. Diflucan; Canadian Brand Name. CanesOral; Descriptions. Fluconazole is used to treat serious fungal or yeast infections, such as vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections.
Chronic mucocutaneous candidiasis. This condition is generally treated with oral azoles, such as fluconazole at a dose of 100-400 mg/d or itraconazole at a dose of 200-600 mg/d until the patient improves. The initial therapy for acute infection is always followed by maintenance therapy with the same azole for life A single oral dose of fluconazole (Diflucan) is increasingly used for treating vaginal candidiasis. Systemic Therapy Systemic infection can occur in the brain, windpipe, kidneys, heart, liver and. Oesophageal candidiasis may uncommonly be complicated by bezoar formation, perforation and fistula formation. If there is severe neutropaenia, oesophagitis may also lead to candidaemia or bacteraemia. Therapy . Systemic therapy is necessary for oesophageal candidiasis in the form of fluconazole 200-400 mg qd for 2-3 weeks Dosage: Administered orally and as injectable. Adult. Vaginal Candidiasis: 150mg for one time dose. Oropharyngeal and Esophageal Candidiasis: 200mg on day 1, then followed by 100mg daily for 14 days. Other Candidiasis: Doses up to 400mg per day until cured. Crytpococcal Meningitis A total of 33 HIV-positive patients with invasive oesophageal Candida infection were given a single oral dose of 400 mg fluconazole and were examined after 3, 7 and 14 d. A second 400 mg dose was given on day 3 if symptoms had not resolved. Altogether, 31 of 33 patients could be cured by a single (27 patients) and double (4 patients) dose of 400 mg fluconazole
Esophageal candidiasis. For the treatment of esophageal candidiasis, the recommended dosage of fluconazole in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Doses up to 12 mg/kg/day may be used, based on medical judgment of the patient's response to therapy Dose-Response Study of Micafungin Compared with Fluconazole for the Treatment of Esophageal Candidiasis in HIV-Positive Patients N. de Wet,1 A. Llanos-Cuentas,4 J. Suleiman,5 E. Baraldi,2 E. F. Krantz,3 M. Della Negra,5 and H. Diekmann-Berndt Esophageal candidiasis is a frequent cause of morbidity in immunocompromised patients. Isavuconazole is a novel, broad-spectrum antifungal developed for the treatment of opportunistic fungal infections. This phase 2 trial compared the efficacy and safety of three oral dosing regimens of isavuconazole with an oral fluconazole regimen in the primary treatment of uncomplicated esophageal. Oropharyngeal and esophageal candidiasis. Adults: 200 mg P.O. or I.V. on day 1 followed by 100 mg P.O. or I.V. once daily. As much as 400 mg daily has been used for esophageal disease. Continue for at least 2 weeks after symptoms resolve. Children: 6 mg/kg on day 1, followed by 3 mg/kg for at least 2 weeks. Systemic candidiasis
50% of serum. Fluconazole urine concentrations reach 10-20 times serum concentrations. Adjust dose for creatinine clearance <50mL/min. • Itraconazole is generally reserved for mucosal candidiasis, and little data exist for IC. GI absorption differs for capsule versus solution Esophageal candidiasis. For the treatment of esophageal candidiasis, the recommended dosage of DIFLUCAN in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Doses up to 12 mg/kg/day may be used, based on medical judgment of the patient's response to therapy Vaginal candidiasis, oropharyngeal and esophageal candidiasis, and cryptococcal meningitis. Tinea versicolor : 200 mg po daily × 5-7 days;200-300 mg weekly × 2-3 weeks; or 400 mg once. Cutaneous candidiasis : 150 mg once weekly given for 2-4 weeks 3. For the treatment of vaginal candidiasis, fluconazole 150mg should be administered as a single oral dose. To reduce the incidence of recurrent vaginal candidiasis, a 150mg once monthly dose may be used. The duration of therapy should be individualized, but ranges from 4-12 months. Some patients may require more frequent dosing The recommended dose of fluconazole to prevent infection in adults undergoing bone marrow transplant is 400 mg once daily. Oropharyngeal candidiasis: in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Esophageal candidiasis: in children is 6 mg/kg on the first day, followed by 3 mg/kg to 12 mg/kg once daily
Diflucan. The usual adult dose is 50-400 mg daily depending on the type of infection. Although symptoms of oral Candida infections may subside in a few days, treatment is continued for 2 weeks. Esophageal Candida infections are treated for 3 weeks or longer Single 200 mg loading dose on Day 1, followed by 100 mg daily dose thereafter. Antifungal therapy should continue for at least 14 days after the last positive culture. Treatment of esophageal candidiasis Single 100 mg loading dose on Day 1, followed by 50 mg daily dose thereafter. Duration of treatment should be for An 1-week regimen of fluconazole (150 mg) 300 mg p.o. qd for candidiasis and Takepron, 30 mg p.o. qd for the esophageal and gastric ulcers was administered. Physical examination at 2-week follow-up revealed complete resolution of hiccups and epigastric distress as well as significant weight gain Esophageal candidiasis For the treatment of esophageal candidiasis, the recommended dosage of DIFLUCAN in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Doses up to 12 mg/kg/day may be used, based on medical judgment of the patient's response to therapy The aim of this study has been to assess, by a double-blind multicenter randomization, the role, the therapeutic efficacy, and the safety of use of fluconazole and itraconazole-flucytosine association, compared with placebo, in the treatment of endoscopically diagnosed esophageal candidiasis in a selected population of AIDS patients, providing.
Fluconazole levels in plasma and vaginal secretions of patients after a 150-milligram single oral dose and rate of eradication of infection in vaginal candidiasis. Antimicrob Agents Chemother 1990. Candidiasis, esophageal Amita Gupta, M.D. and Karen Wendel, M.D. If endoscopy not possible, pts should generally be treated with a different antifungal agent or with higher dose of fluconazole (if initially placed on an empiric fluconazole regimen) prior to empiric treatment for other common causes of esophagitis
For esophageal candidiasis, half of this dose. Hepatitis, diarrhea, hypokalemia, infusion reactions. Caspofungin. Aspergillosis. This water-soluble drug is absorbed almost completely after an oral dose. Fluconazole is excreted largely unchanged in urine and has a half-life of > 24 hours,. Oropharyngeal Candidiasis Adult: PO/IV 200 mg day 1, then 100 mg q.d. x 2 wk Child: PO/IV 3-6 mg/kg/d Esophageal Candidiasis Adult: PO/IV 200 mg day 1, then 100 mg q.d. x 3 wk Child: PO/IV 3-6 mg/kg/d Systemic Candidiasis Adult: PO/IV 400 mg day 1, then 200 mg q.d. x 4 wk Child: PO/IV 3-6 mg/kg/d Vaginal Candidiasis Adult: PO 150 mg x 1. Vaginal candidiasis: The recommended dose of diflucan for the treatment of candidiasis of vagina is 150 mg. It is taken as a single dose for the treatment of vaginal candidiasis. Oral and esophageal candidiasis: The recommended dose for the treatment of candida infection of oral cavity and esophagus is 200 mg the first day. The initial dose is.
Funginazol (Fluconazole) is an antifungal drug; it inhibits fungal cytochrome P450 dependent enzymes, resulting in blocked ergosterol synthesis. Funginazol is used in the treatment of vaginal candidiasis, oropharyngeal and esophageal candidiasis, dermal candidal infections, systemic candidal infections, acute cryptococcal meningitis. Esophageal thrush warrants systemic antifungal therapy, and anantifungal medication, such as itraconazole, will likely be prescribed. This prevents the fungus from spreading and works to eliminate. fluconazole; treatment-related adverse events occurred in 9.3% and 12.0% of patients, respectively. Laboratory parameters were similar between treatment arms. Anidulafungin is as safe and effective as oral fluconazole for the treatment of esophageal candidiasis, when assessed at the completion of therapy
Caspofungin is a new echinocandin drug with comparable in vitro activity against azole-susceptible and -resistant isolates of that could provide a less toxic alternative to amphotericin B for the management of esophageal candidiasis with clinical or laboratory evidence of decreased susceptibility to fluconazole Chronic mucocutaneous candidiasis treatment is as follows: Patients with associated endocrine abnormalities, such as those involving the parathyroid, should have electrolytes monitored and corrected as necessary. Initial: 400-800 mg oral fluconazole once a day for 4-6 months. Maintenance: 200 mg oral fluconazole once a day
Rated for Vaginal Candidiasis Report . I will not recommend this medicine to anyone. I started to use fluconazole 150mg 5 months ago. And everything was ok in the beginning but with the 3rd dose on third week my pelvic area was numb. I told this to my gynecologist but she ignored saying this is becoz of infection and I continued to use this. Esophageal Candidiasis. For the treatment of esophageal candidiasis, the recommended dosage of fluconazole in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Doses up to 12 mg/kg/day may be used based on medical judgment of the patient's response to therapy
No history of esophageal candidiasis. No presence of systemic fungal infection requiring continuous antifungal therapy. No use of continuous azole treatment (i.e. daily, weekly, every other day, twice weekly fluconazole, itraconazole, ketoconazole or coltrimazole) for the prevention of fungal infections greater than or equal to 1 month within. A total of 6 (14.28%) samples were resistant to fluconazole, while 2 (4.76%) samples had dose depending susceptibility to this drug. CONCLUSIONS: Esophageal candidiasis prevalence was low, although within the results described by other authors
Esophageal Candidiasis. The data described below reflect exposure to anidulafungin and fluconazole in 300 and 301 patients, respectively, with esophageal candidiasis in a randomized trial comparing the efficacy and safety of anidulafungin to that of oral fluconazole. In anidulafungin-treated patients, the age range was 18-68 years, the gender distribution was 42% male and 58% female and the. Esophageal Candidiasis f 200 mg q12hf Scedosporiosis and Fusariosis 6 mg/kg q12h for the first 24 hours 4 mg/kg q12h 200 mg q12h a Increase dose when voriconazole for oral suspension is co-administered with phenytoin or efavirenz (7); Decrease dose in patients with hepatic impairment (2.7 therapy can be maximized by using a dose of 4 mg/kg rounded up to convenient tablet sizes. For seriously ill individuals, the parenteral formulation is recommended(. IDSA, 2016) Candidiasis: For esophageal candidiasis, fluconazole is the treatment of choice for esophageal candidiasis. For fluconazole-refractory disease, itraconazole. Esophageal candidiasis fluconazole treatment February 10, 2019 by admin 3 Min Reading Candidiasis of the esophagus is one of the manifestations of the general defeat of the gastrointestinal tract by pathogenic microorganisms
Fluconazole is an antifungal medicine. It's used to treat many types of fungal infections that affect different parts of the body, including the following areas 5 main antifungal medications used for treatment of oral candidiasis. Nystatin. Clotrimazole. Econazole. Diflucan. Miconazole. Nystatin. tablets, creams, or liquid suspensions. - adult dose: one tablet 3 times daily, this dosage can be increased to 2 tablets 3 times daily if necessary Neutropenic patients with severe Esophageal candidiasis symptoms or at high risk for dissemination can be started on: select all that apply A. Echinocandin B. Amphotericin B C. Itraconazole solution D. High dose Fluconazole